Hours Of Operations Rue 21 South Carolina Seneca Rue 21 Hours of Operation and Locations in Seneca, SC 4.5 - 48 votes 1 Locations in Seneca rue21.com Rue 21 Hours Category: Apparel Grocery & Market Rue 21 - Seneca, SC 29678 251 Applewood Center Pl(864) 885-1560 View Store Details Explore SenecaView More Apparel KmartBig LotsCatoHamrick'sCarhartt Sports All Sports Jewelry CatoBelk Recommend For You American Furniture Warehouse Raymour & Flanigan Jo-Ann Fabric and Craft Centurylink Sport Chalet Brandy Melville The Vitamin Shoppe Performance Bicycle The Children's Place Custom Ink