Hours Of Operations Rue 21 South Carolina Florence 29501 Rue 21 Hours of Operation and Location in Florence, SC 29501 4.4 - 97 votes 2861 David H Mcleod Blvd, Florence, SC 29501 (843) 413-5272 Get Directions Rue 21 Hours Category: Apparel Grocery & Market Hours Hours may vary due to season or holiday reasons. For specific hours, please contact store directly. Map Explore FlorenceView More Apparel Sam's ClubTJ MaxxRoss Dress for LessKmartBig Lots Sports TargetDick's Sporting GoodsColemanAcademy Sports + OutdoorsMotherhood Maternity Jewelry Sam's ClubHobby LobbyCatoZalesKohl's Outlet Recommend For You The Vitamin Shoppe The Children's Place Dick's Sporting Goods Ross Stores Yankee Candle New York & Company Grainger Cosmo Prof ADT J. C. Penney