Hours Of Operations Rue 21 South Carolina Florence Rue 21 Hours of Operation and Locations in Florence, SC 4.5 - 48 votes 1 Locations in Florence rue21.com Rue 21 Hours Category: Apparel Grocery & Market Rue 21 - Florence, SC 29501 2861 David H Mcleod Blvd(843) 413-5272 View Store Details Explore FlorenceView More Apparel Sam's ClubTJ MaxxRoss Dress for LessKmartBig Lots Sports TargetDick's Sporting GoodsColemanAcademy Sports + OutdoorsBlades Jewelry Sam's ClubHobby LobbyCatoZalesKohl's Outlet Recommend For You American Furniture Warehouse Raymour & Flanigan Jo-Ann Fabric and Craft Centurylink Sport Chalet Brandy Melville The Vitamin Shoppe Performance Bicycle The Children's Place Custom Ink