Hours Of Operations Rue 21 North Carolina Wilkesboro 28697 Rue 21 Hours of Operation and Location in Wilkesboro, NC 28697 4.1 - 128 votes 1815 Us Highway 421, Wilkesboro, NC 28697 (336) 667-1741 Get Directions Rue 21 Hours Category: Apparel Grocery & Market Hours Hours may vary due to season or holiday reasons. For specific hours, please contact store directly. Map Explore WilkesboroView More Apparel Big LotsCatoCarharttCarter'sJCPenney Jewelry CatoKohl's OutletBelk Recommend For You J. C. Penney Champion Game Stop Goodwill I wireless Bob's Stores Bargain Shop Carter's El Toro Market Advanced Electronics