Hours Of Operations Rue 21 North Carolina Wilkesboro Rue 21 Hours of Operation and Locations in Wilkesboro, NC 4.5 - 48 votes 1 Locations in Wilkesboro rue21.com Rue 21 Hours Category: Apparel Grocery & Market Rue 21 - Wilkesboro, NC 28697 1815 Us Highway 421(336) 667-1741 View Store Details Explore WilkesboroView More Apparel Big LotsCatoCarharttCarter'sJCPenney Jewelry CatoKohl's OutletBelk Recommend For You American Furniture Warehouse Raymour & Flanigan Jo-Ann Fabric and Craft Centurylink Sport Chalet Brandy Melville The Vitamin Shoppe Performance Bicycle The Children's Place Custom Ink