Hours Of Operations Rue 21 Missouri Cape Girardeau 63703 Rue 21 Hours of Operation and Location in Cape Girardeau, MO 63703 4.0 - 93 votes 3049 William St, #143, Cape Girardeau, MO 63703 (573) 334-7898 Get Directions Rue 21 Hours Category: Apparel Grocery & Market Hours Hours may vary due to season or holiday reasons. For specific hours, please contact store directly. Map Explore Cape GirardeauView More Apparel Sam's ClubTJ MaxxColdwater CreekKmartBig Lots Sports TargetColemanAcademy Sports + OutdoorsVitamin WorldLids Jewelry Sam's ClubHobby LobbyCatoKohl's OutletKay Jewelers Recommend For You New York & Company Cosmo Prof ADT J. C. Penney At Home Crossfit Deb Esprit Ferguson Forever21