Hours Of Operations Rue 21 Missouri Cape Girardeau Rue 21 Hours of Operation and Locations in Cape Girardeau, MO 4.5 - 48 votes 1 Locations in Cape Girardeau rue21.com Rue 21 Hours Category: Apparel Grocery & Market Rue 21 - Cape Girardeau, MO 63703 3049 William St, #143(573) 334-7898 View Store Details Explore Cape GirardeauView More Apparel Sam's ClubTJ MaxxColdwater CreekKmartBig Lots Sports TargetColemanAcademy Sports + OutdoorsVitamin WorldLids Jewelry Sam's ClubHobby LobbyCatoKohl's OutletKay Jewelers Recommend For You American Furniture Warehouse Raymour & Flanigan Jo-Ann Fabric and Craft Centurylink Sport Chalet Brandy Melville The Vitamin Shoppe Performance Bicycle The Children's Place Custom Ink