Hours Of Operations Rue 21 Massachusetts Hyannis 02601 Rue 21 Hours of Operation and Location in Hyannis, MA 02601 4.1 - 116 votes 793 Iyannough Rd, #E143a, Hyannis, MA 02601 (508) 790-5908 Get Directions Rue 21 Hours Category: Apparel Grocery & Market Hours Hours may vary due to season or holiday reasons. For specific hours, please contact store directly. Map Explore HyannisView More Apparel MarshallsTJ MaxxKmartCarharttCarter's Sports Sports AuthorityVansColemanEastern Mountain SportsFinish Line Jewelry MarshallsZalesKohl's OutletKay JewelersChico's Recommend For You Jo-Ann Fabric and Craft The Vitamin Shoppe The Children's Place Yankee Candle New York & Company Sleep Number Cosmo Prof ADT At Home Bianchi