Hours Of Operations Rue 21 Kentucky Owensboro 42301 Rue 21 Hours of Operation and Location in Owensboro, KY 42301 4.3 - 54 votes 5000 Frederica St, #F7, Owensboro, KY 42301 (270) 684-7262 Get Directions Rue 21 Hours Category: Apparel Grocery & Market Hours Hours may vary due to season or holiday reasons. For specific hours, please contact store directly. Map Explore OwensboroView More Apparel Sam's ClubTJ MaxxKmartBig LotsCato Sports TargetRural KingFinish LineFrank's Sports ShopGolfland Jewelry Sam's ClubHobby LobbyCatoKohl's OutletKay Jewelers Recommend For You Cosmo Prof ADT J. C. Penney Benjamin Moore Carter Lumber Champion Chem-Dry Danner Deb Ferguson