Hours Of Operations Rue 21 Florida Lake City 32055 Rue 21 Hours of Operation and Location in Lake City, FL 32055 4.3 - 107 votes 2469 W Us Highway 90, #179, Lake City, FL 32055 (386) 719-2089 Get Directions Rue 21 Hours Category: Apparel Grocery & Market Hours Hours may vary due to season or holiday reasons. For specific hours, please contact store directly. Map Explore Lake CityView More Apparel TJ MaxxBig LotsCarharttBeallsCarter's Sports VansColemanSporting Goods Incorporated Jewelry BeallsBelkKay JewelersAvon Recommend For You Floor & Decor New York & Company J. C. Penney At Home Builders First Source Champion Chem-Dry Deb Ferguson Goodwill