Hours Of Operations Rue 21 California Hesperia Rue 21 Hours of Operation and Locations in Hesperia, CA 4.5 - 48 votes 1 Locations in Hesperia rue21.com Rue 21 Hours Category: Apparel Grocery & Market Rue 21 - Hesperia, CA 92345 12728 Main St(760) 948-6959 View Store Details Explore HesperiaView More Apparel MarshallsRoss Dress for LessKmartH & MCarhartt Sports TargetRoxySnap FitnessJazzerciseBasic Basic Jewelry MarshallsAvonCarriage House AntiquesNew to You Recommend For You American Furniture Warehouse Raymour & Flanigan Jo-Ann Fabric and Craft Centurylink Sport Chalet Brandy Melville The Vitamin Shoppe Performance Bicycle The Children's Place Custom Ink