Hours Of Operations Lowe's Missouri Sikeston Lowe's Hours of Operation and Locations in Sikeston, MO 4.6 - 205 votes 1 Locations in Sikeston Lowe's Hours Category: Home & Garden Lowe's - Sikeston, MO 63801 1240 S. Main St(573) 472-7800 View Store Details Explore SikestonView More Apparel Goody'sCatoCarharttCarter'sJCPenney Sports ColemanBasic BasicBladesCity Gear Jewelry CatoDressbarn Outlet Recommend For You High's of Baltimore Krauszer's Food Store Eileen Fisher North Face Quality Mart Dakota Watch Company Glitter Pak-A-Sak Cavender's Madewell