Hours Of Operations Lowe's Home Improvement Missouri Sikeston Lowe's Home Improvement Hours of Operation and Locations in Sikeston, MO 4.8 - 142 votes 1 Locations in Sikeston www.lowes.com Lowe's Home Improvement Hours Category: Home & Garden Lowe's Home Improvement - Sikeston, MO 63801 1240 S Main St(573) 472-7800 View Store Details Explore SikestonView More Apparel Goody'sCatoCarharttCarter'sJCPenney Sports ColemanBasic BasicBladesCity Gear Jewelry CatoDressbarn Outlet Recommend For You Lower Corner Soccer Store Lucky Dollar Lucky Supermarket Luis Garage Doors & Gates Lupita Grocery LYNX-USA Incorporated M & G Variety Store M & M Grocery Madison Industries Incorporated Magic Clean Carpet