Hours Of Operations Home Depot Kentucky Owensboro Home Depot Hours of Operation and Locations in Owensboro, KY 4.9 - 147 votes 1 Locations in Owensboro Home Depot Hours Category: Home & Garden Home Depot - Owensboro, KY 42301 5150 Us 431-Frederica St(270) 683-9923 View Store Details Explore OwensboroView More Apparel Sam's ClubTJ MaxxKmartBig LotsCato Sports TargetRural KingFinish LineFrank's Sports ShopGolfland Jewelry Sam's ClubHobby LobbyCatoKohl's OutletKay Jewelers Recommend For You CVS Target IKEA Michaels Costco Marshalls Sports Authority Walgreens Publix Great Clips